{"id":2519,"date":"2023-03-20T16:09:48","date_gmt":"2023-03-20T15:09:48","guid":{"rendered":"https:\/\/lab.alara-expertise.fr\/2023\/03\/20\/health-related-quality-of-life-and-overall-survival-a-prospective-study-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy\/"},"modified":"2023-04-27T11:44:29","modified_gmt":"2023-04-27T09:44:29","slug":"health-related-quality-of-life-and-overall-survival-a-prospective-study-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy","status":"publish","type":"post","link":"https:\/\/spin-up.fr\/en\/2023\/03\/20\/health-related-quality-of-life-and-overall-survival-a-prospective-study-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy\/","title":{"rendered":"Health-related quality of life and overall survival: a prospective study in patients with head and neck cancer treated with radiotherapy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2519\" class=\"elementor elementor-2519\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c62b14a elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c62b14a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1164310\" data-id=\"1164310\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b8a972 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b8a972\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f7aa4fb\" data-id=\"f7aa4fb\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-69fc6f4 elementor-align-left elementor-widget elementor-widget-post-info\" data-id=\"69fc6f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-5eb95cd elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<a href=\"https:\/\/spin-up.fr\/en\/category\/monitoring\/\" class=\"elementor-post-info__terms-list-item\">Monitoring<\/a>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c948f4 elementor-widget elementor-widget-elementskit-heading\" data-id=\"3c948f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Health-related quality of life and overall survival: a prospective study in patients with head and neck cancer treated with radiotherapy<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider ekit-dotted\"><div class=\"elementskit-border-divider ekit-dotted\"><\/div><\/div>\t\t\t\t<div class='ekit-heading__description'>\n\t\t\t\t\t<p><em><strong>Titre original :<\/strong> \u00ab Health-related quality of life and overall survival: a prospective study in patients with head and neck cancer treated with radiotherapy \u00bb publi\u00e9 en d\u00e9cembre 2020 dans le journal \u201cQuality of Life Research\u201d.<\/em><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb3cc77 elementor-widget elementor-widget-heading\" data-id=\"eb3cc77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Interest of the study<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-162c638 elementor-widget elementor-widget-text-editor\" data-id=\"162c638\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The objective of this prospective study was to examine whether pre- and post-treatment quality of life is associated with survival, after adjusting for demographic, clinical, and lifestyle factors in patients with head and neck cancer.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a43870 elementor-widget elementor-widget-heading\" data-id=\"7a43870\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Method<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4012965 elementor-widget elementor-widget-text-editor\" data-id=\"4012965\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les auteurs ont constitu\u00e9 une cohorte de 948 patients atteints de cancer de la t\u00eate et du cou nouvellement diagnostiqu\u00e9s et trait\u00e9s par (chimio)radioth\u00e9rapie primaire ou adjuvante avec intention curative.<\/p>\n<p>They evaluated the patients&#8217; quality of life in the form of a questionnaire, including a large number of variables, particularly environmental. These questionnaires were completed by the patients before their treatment, as well as at different times after treatment (6 weeks, 6 months and 12 months).<\/p>\n<p>The results obtained were analyzed according to the Cox model, a multivariate logistic regression approach commonly used in medical research to analyze survival time data as a function of a set of covariates (here, factors associated with quality of life).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73035c9 elementor-widget elementor-widget-heading\" data-id=\"73035c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Results<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bc1bb5 elementor-widget elementor-widget-text-editor\" data-id=\"9bc1bb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8211; Better quality of life is significantly associated with longer survival, after adjustment for demographic, clinical, and lifestyle factors. These criteria include overall quality of life, physical activity, emotional, cognitive, and social status before treatment and at 6 weeks, 6 months, and 12 months after treatment.<\/p>\n<p>&#8211; Quality of life measured 6 weeks after treatment compared with the situation before treatment was not significantly associated with survival. This may be due to the fact that shortly after treatment, many patients are still suffering from the acute side effects of the treatment and therefore the short-term change in quality of life is not yet a discriminating factor. Most of these acute side effects disappear after 6 months of treatment.<\/p>\n<p>&#8211; Decreased physical activity and worsened emotional state (including &#8220;depressive symptoms&#8221;) at 6 and 12 months after treatment were significantly associated with shorter survival. This association had already been demonstrated in previous studies on different types of cancers, including breast cancer.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71eb3d3 elementor-widget elementor-widget-heading\" data-id=\"71eb3d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ef5c8c elementor-widget elementor-widget-text-editor\" data-id=\"8ef5c8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8211; Tracking changes in quality of life (especially physical activity, and emotional state) over time in clinical practice seems important, as these scores may be sensitive in signaling clinical deterioration. Monitoring of symptoms (such as dyspnea, fatigue, and pain) in routine patient care appears to be associated with increased survival compared with usual care. This may be due to nurses&#8217; early responses to symptom alerts with clinical interventions and better tolerance of chemotherapy compared with the usual care group.<\/p>\n<p>Monitoring quality of life in clinical practice can identify patients at risk following treatment. This could further improve cancer care in a timely and effective manner.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3071b39 elementor-widget elementor-widget-heading\" data-id=\"3071b39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Our solutions<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9350965 elementor-widget elementor-widget-text-editor\" data-id=\"9350965\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our rapid tests reflect our desire to personalize medicine by optimizing both the effectiveness of radiotherapy treatments and the prevention of toxicities.<\/p>\n<p><b>We have developed a predictive model of acute toxicity after radiation therapy for patients with ENT cancers, using both our RADIODTECT\u00ae test, and dosimetric factors of normal tissues.<\/b><\/p>\n<p>We do not all have the same sensitivity to radiation as used in radiotherapy. Measuring this radiosensitivity makes it possible to assess the risk of side effects before treatment and thus improve the overall quality of life of treated patients.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18b0317 elementor-widget elementor-widget-spacer\" data-id=\"18b0317\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0956250 elementor-widget elementor-widget-heading\" data-id=\"0956250\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Share this 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